Introduce yourself, ask for the name of the person who handles cabinet nominations, and share where you're from. ("Hi, this is Joe calling from Wilmington, Delaware. Can I speak to the person in your office who handles cabinet nominations?")
State the reason you are calling and the specific action you want your senator to take — you oppose Betsy DeVos' nomination for Secretary of Education and ask your senator to vote against her confirmation.
Share how the call went on Facebook and Twitter and encourage your friends to reach out to their senator.